Kenneth and Howard Thede

Kenneth Thede (left) and Howard Thede, photograph ca. 1922, Wayland, MI
 



Testing Candidates for L555, L557 & L561

The only surname currently testing positive for these SNPs is Irwin (and variants of the Irwin surname). There are currently around 83 known submissions that have a very high probably of testing positive (match over 70 % of the L555 fingerprint). There are another 67 submissions that match between 50 and 70 % of the L555. Several submissions below 70 % could test postive for L555 but the vast majority of these submissions would probably not test positive. This is based on the number of testing candidates drops off radically above 70 % and then starts increasing rapidly below 70 % which implies a boundary condition for L555. Since L555 is dominated by Irwin variant surnames, it is highly recommended that you also review additional information at the Clan Irwin DNA web site:

http://dnastudy.clanirwin.org/latest-results

There are around 83 very good candidates for the testing of L555, L557 & L561 (above 70 % of the L555 fingerprint). There are also another 67 reasonable candidates for testing (that test match the fingerprint between 50 and 70 % of the L555 fingerprint):

1) There area at least 83 very good testing candidates that match over 70 % of the L555 fingerprint. With ten submissions testing positive for L555 above 70 %, it is only recommended that submissions that match 6 of 8 matches of the L555 fingerprint test for L555. Only a few of these 6 of 8 matches will probably test negative but would greatly help identify the boundary STR values, the breadth of the L555 SNP and possible improvements in the fingerprint for better SNP prediction. Only Irwin variant surnames have been tested to date which introduces bias due to testing of only one surname. Good bourndary condition testing candidates would be: Wilson (X8HZJ & 4ZSFZ), Baird (TMZCX), Vowles (257JY / 75137) and Bivens (VQ3YA).

2) There are around another 67 reasonable candidates (match between 50 and 70 % of the L555 fingerprint). Since most of these submissions will probably test negative, it is recommended that ony the 5 of 8 matches (63 % matches) test for L555 until the breadth of this SNP is better determined. Dunbar (7 submissions) and Blackburn (5 submissions) are dominant surnames that could be related to the Irwin surname. Good boundary condition testing candidates include: Dunbar (69QK7, DHTEX, 7EDXJ, SB7WT, NHKV8, 3PJNZ and W24YX), Blackburn (H7E4K, GSMDU, NXXV4, QDW6K and NAJCC), Brady (HCF2T), Matheson (3YXR2), Mowbray (KKS2K), Hercus (P7C6K), Frain (GJHBA), Campbell (HQ36N), Stroh (VNC7Y), Newman (Z36FE), McDonald (YBP9S) and Calhoun (TU32Y). There is only one Irwin variant submissions that matches at either a 4 of 8 or a 5 of 8 fingerprint matches. It is highly recommended that the Erwin submission (211473) be tested for all three SNPs to test the boundary of these SNPs for the Irwin surname surname.

It is not certain the breadth of L555, L557 and L561 which is only currently being tested in the Clan Irwin surname project. There are no active plans to test non-Irwin surnames at this point in time. The Irwin project is first testing L555 to determine the breadth of these SNPs within the Irwin surname cluster associated with L555. After ten tests of Irwin variant submissions, it does not appear that these SNPs will produce branches within the project as was hoped for. It is highly recommended that other non-Irwin surname candidates starting being tested for L555 a 5 of 8 fingerprint match. If many 5 of 8 matching submissions test positive for L555, the testing would then be expanded to 4 of 8 fingerprint matches.